The Association between Microalbuminuria and Plasma Fibrinogen Levels in Type 2 Diabetic Sudanese Patients

Aims: Increased plasma fibrinogen considered as one of the underlying complications caused by type 2 diabetic, proteins overproduction is associated with albuminuria in non-dibetic individuals. It is not known whether the presence of albuminuria in patients with type 2 diabetes mellitus is associated with greater albumin and fibrinogen production rates, so the present study was designed to investigate the association of the fibrinogen levels in type 2 diabetic patients with and without microalbuminuria compared with normal subjects. Materials & Methods: Plasma fibrinogen level was assessed in 140 individuals; 110 diagnosed as type 2 diabetic patients, furthermore they were classified into two groups according to the urinary excretion rates of albumin, 55 patients with microalbuminuria, 55 patients without microalbuminuria, and 30 non diabetic subjects as control. Results: Diabetic patients group had a higher mean value of plasma fibrinogen (M±SD = 3.751±0.934) compared with control group (M±SD= 3.296±0.590) (P= 0.013), and in diabetic patients subgroups; patients with microalbuminuria had a higher mean value of fibrinogen (M±SD= 4.039±0.976) compared to diabetic patients without microalbuminuria (M±SD= 3.463±0.798) (P= 0.001). In addition to that, the study noticed that, the plasma fibrinogen level was positively correlates with the duration of diabetes; (P= 0.002). Conclusion: The study concluded that the plasma fibrinogen level was significantly elevated in Type 2 diabetic patients with microalbuminuria, and also the fibrinogen level correlates with duration of diabetes.